dup(21q) amplified (RUNX1)
نویسندگان
چکیده
منابع مشابه
RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.
RUNX1 is a transcription factor that regulates critical processes in many aspects of hematopoiesis. RUNX1 is also integral in defining the definitive hematopoietic stem cell. In addition, many hematological diseases like myelodysplastic syndrome and myeloproliferative neoplasms have been associated with mutations in RUNX1. Located on chromosomal 21, the RUNX1 gene is involved in many forms of c...
متن کاملRUNX1 and breast cancer
RUNX1 is a member of the RUNX family of transcription factors that also includes RUNX2 and RUNX3 [1]. Early studies identified RUNX1 as a key regulator of definitive hematopoiesis and the role of RUNX1 as a tumor suppressor in leukemia is well established [1]. In more recent sequencing studies of solid tumors, molecular alterations have been identified in other cancer types, suggesting a broade...
متن کاملRUNX1 translocations in malignant hemopathies.
The RUNX gene family includes three evolutionarily conserved genes (RUNX1, RUNX2 and RUNX3) encoding transcription factors involved in cell lineage differentiation during development and various forms of cancer. The RUNX1 gene, located in chromosome 21q22, is crucial for the establishment of definite hematopoiesis and the generation of hematopoietic stem cells in the embryo. It contains a "Runt...
متن کاملRUNX1 as a recombinase cofactor
The regulation of TCR rearrangements, particularly of TCRδ and TCRβ, plays a decisive role in lymphoid differentiation and oncogenic transformation. Somatic assembly of TCR loci is established through V(D)J recombination during lymphocyte development. All V, (D) and J gene segments are flanked with recombination signal sequences (RSS) which are composed of conserved heptamer and nonamer motifs ...
متن کاملThe mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters.
The transcription factor Runx1 plays a pivotal role in hematopoietic stem cell (HSC) emergence, and studies into its transcriptional regulation should give insight into the critical steps of HSC specification. Recently, we identified the Runx1 +23 enhancer that targets reporter gene expression to the first emerging HSCs of the mouse embryo when linked to the heterologous hsp68 promoter. Endogen...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/38300